I experienced two different specific items: 1 was a local PBX with a fixed IP4 address. A Grandstream phone 2140 configured with DHCP worked fine, but then when IP6 started to hand off the DHCP and no IP4, problems arose. Likewise, on the other problem I encountered, a phone that supported both IP4 and 6 was set to register to a remote DNS of pbx.office.com which had a public IP4 address. Using the NAT=YES on the PBX resulted in things working great (when the phone was grabbing an IP4 private IP). When the comcast router started handing out IP6, it failed to work. I had to manually set the phone to a static private IP4 address and then it worked fine, as I didn't see how to disable the IP6 DHCP forcing IP4 on the comcast router.
I got all things working fine, I just think in the future more and more people are going to experience these types of issues if carriers start to push the IP6 while people are still using the IP4. For example, with the remote PBX, I assume the NAT=yes is configured to work and works well with IP4, but when one end is IP6 and the other is IP4, I wonder if it chokes on it.